Balsamiq Mockups is a desktop and web app for designing web, mobile and other user interfaces layouts and wireframes.
After seeing the wireframes provided by a client and finding out this is what was used to generate them, I downloaded a trial version. Within minutes I purchased the full version and we have used it on several projects since.
The sketchy look of the mockups is ideal as it doesn’t impart any unintended design cues to the designer and lets the wireframes focus on the functionality and UI decisions.
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